The Real Differences Between 1P-LSD and LSD-25

I am getting real fed up with these children not understanding how to use google stating that these are unique medications. **First lets examine metabolites:** [In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures.](https://www.ncbi.nlm.nih.gov/pubmed/30617391) >Total, N-dealkylation and hydroxylation, in addition to mixtures of those steps mostly catalyzed by CYP1A2 and CYP3A4, were discovered. To get ALD-52, 1P-LSD, and 1B-LSD, deacylation to LSD has been detected. There does appear to be a scarcity of information on the pharmacokinetics, but it’s clear it’s metabolised to LSD. **However, how does it really compare to LSD? ** [Return of the lysergamides. Part I: Analytical and behavioral characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829483/) It had been discovered that 1P-LSD generated a dose-dependent growth in HTR counts, which it’d ~38percent (ED50 = 349.6 nmol/kg) of this effectiveness of LSD (ED50 = 132.8 nmol/kg). What’s more, the HTR was abolished when 1P-LSD government followed pre-treatment using the discerning 5-HT2A receptor antagonist M100907 (0.1 mg/kg, SC), which affirms that the behavioral reaction is mediated by activation of this 5-HT2A receptor. These results imply that 1P-LSD generates LSD-like consequences in mice, consistent with its classification as a serotonergic hallucinogen. Nonetheless, the degree to which 1P-LSD may reveal side effects in humans like LSD remains to be researched. This lack of effectiveness is to be anticipated with an expert drug **Psychedelics are different each time** That is something I do not have a supply for, but I really don’t think that it’s needed. In the event you should take 3.5 g of mushrooms now, then 1 year from today, you take 3.5 g, the excursions can be wholly different from one another. This large part has to do with how psychedelics work out from your sense at the moment and in which you are in life then. In summary, google until you inquire, and quit indicating that both of these medications are indeed distinct from one another when the differences are second.

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25 thoughts on “<p>The Actual Differences Between 1P-LSD and LSD-25”
  1. Approved and pinned for a while cause I agree. I’ve been quite absent in the little details of this sub for a few months now but I definitely see a fuck load of posts about 1P VS 25, enough that maybe this is a good idea to pin it.

  2. Hell yes to the last point. I’ve had trips on the same chemical, from the same batch, at the same dose, and if I didn’t know better could absolutely be convinced I took a different drug.

  3. Thanks for posting this. I’m 45 and quite experienced with LSD-25 but have been out of touch for the most part with psychedelics except for a few occasions over the last ten or twelve years and was somewhat confused as to the metabolization of 1-P and was hesitant to experiment with it. I feel much more confident now that I’m not dealing with something completely novel. Thanks again and great papers by the way.

  4. Well they have different CAS numbers and all are therefore different drugs, with almost indistinguishable effects
    This is probably like psilocybin and psilocin. Psilocybin probably does not cross the BBB and requires its metabolism to psilocin for effect.

    But conversely I have taken 4-AcO-DMT and psilocin and they are very different while many people,
    My wife included thought they were identical.

    In some of these prodrug cases variance in an individuals metabolism could play a role in which drug is more abundantly expressed in the nervous system, as long as said prodrug is able to cross the BBB on its own.

  5. I’m still curious about the time it takes to metabolize into lsd. If I take the LSD it works fast and all hits at once, so to speak. If 1p wouldn’t it take time and happen gradually causing it to peak lower and also have the tolerance effect just like trying to redose with LSD? Seems fine for low dose, but how about heroic doses? I’m not experienced with it, and I’m truly wanting to know if this is a thing or not.

  6. The only difference i noticed was that the colors and closed eye visuals were less vivid and intense on 1P vs Regular LSD… not to say that i didnt enjoy my 1P trip, it was pretty crazy… but i did miss the bright rainbow colors

  7. It actually doesn’t mean those are the same shit. It means that after ingesting it is metabolised to LSD-25 which metabolites can be found in urine. Just it.
    It doesn’t mean it’s the same thing and you have even quoted this “Nevertheless, the extent to which 1P-LSD might show psychoactive effects in humans similar to LSD remains to be investigated.”.
    It says clearly that it produces similar effects and not that it’s the same.
    Your whole post is just LMAO.

  8. oh so this is what all the peoplel who think they are doing the lsd from back in the day are doing nowadays. shows up on a reagent test as lsd.

    once it is metablized it is in a different part of your body so they effects are different than pure lsd-25.

  9. Hey im new to really the community as a whole to my understanding its kinda like same destination different routes meaning the peaks are the same but ive read that the come ups are different

  10. I get the first part but your random stance on it can be different is kinda obvious no one says it’ll be the same every time I don’t think I’ve heard anyone ever say that, not many people even say the first part it’s quite clear already

  11. Absolutely true, until we get pharmacokinetic data its all just anecdotal.

    The thing is due to the enzymes we have, it is widely thought that it is deacetylated in vivo, turning it into psilocin, therefore it should be similar. I know people who are very experienced with both who say they are identical

    I, however am experienced but think 4acoDMT is completely different, more DMT like than mushrooms

    The theory is that maybe folks like us lack large amounts of the enzyme or the enzyme is shaped a little different and a noticeable amount of 4acodmt makes it to the brain.

    Very interesting and a for sure paper in a high tier journal if you do the study

  12. From what I’ve seen in class 1p metabolizes into LSD so they are 95% the same but because of the extra pieces to molecule it causes a harder come up but after that the chemicals are THR exact same but every trip will be diff based on mindset(set) and where u are hanging out at (setting)

  13. Ald is noce but it’s also metabolizes to LSD after THR liver but due to the difference in molecules between ald and 1p THR come up is way diff but THR trip is exactly the same chemical wise. Again your mindset(set) and where ur at(setting).

  14. >If you were to take 3.5 grams of mushrooms today, then one year from now, you again take 3.5 grams, the trips can be completely distinct from one another. This in large part has to do with how psychedelics work off of how your feeling in that moment and where you are in life at that time.

    Yessss!! Mind blown.

  15. I unsubbed from here because when I’ve posted studies like this in the past they get ignored and/or ridiculed. Shame to see not a lot has changed in here, still a bunch of kids!

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